再生医療を用いた治療

英文原著

1. Tanaka R, Vaynrub M, Masuda H, Ito R, Kobori M, Miyasaka M, Mizuno H, Warren SM, Asahara T: Quality-control culture system restores diabetic endothelial progenitor cell vasculogenesis and accelerates wound closure. Diabetes 62:3207-3217, 2013
    

2. Tanaka R, Masuda H, Kato S, Imagawa K, Kanabuchi K, Nakashioya C, Yoshiba F, Fukui T, Kobori M, Wada M, Asahara T, Miyasaka M: Autologous G-CSF mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic non-healing ulcer. Cell Transplant 23：167-179, 2014
    

3. Masuda H, Tanaka R, Fujimura S, Ishikawa M, Akimaru H, Shizuno T, Sato A, Okada Y, Iida Y, Itoh J, Itoh Y, Kamiguchi H, Kawamoto A, Asahara T: Vasculogenic conditioning of peripheral blood mononuclear cells promotes endothelial progenitor cell expansion and phenotype transition of anti-inflammatory macrophage and T lymphocyte to cells with regenerative potential. J Am Heart Assoc 3(3): e000743.2014
    

4. Tanaka R, Masuda H, Fujimura S, Hirano-Ito R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N, Asahara T: Quality-quantity control culture enhances vasculogenesis and wound healing efficacy of diabetic peripheral blood CD34+ cells. Stem Cells Translational Medicine 7(5)428-438, 2018
    

5. Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S, Mizuno H: Human Peripheral Blood Mononuclear Cells Enriched in Endothelial Progenitor Cells via Quality and Quantity Controlled Culture Accelerate Vascularization and Wound Healing in a Porcine Wound Model. Cell Transplantation 27(7):1068-1079, 2018
    

6. Geeroms M, Hamdi M, Hirano R, Hagiwara H, Fujimura S, Mizuno H, Tanaka R: Quality and Quantity Cultured Murine Endothelial Progenitor Cells Increase Vascularization and Decrease Fibrosis in the Fat Graft. Plastic and Reconstructive Surgery, 143(4):744e-755e. 2019
    

7. Geeroms M, Fujimura S, Aiba E, Orgun D, Arita K, Kitamura R, Senda D, Mizuno H, Hamdi M, Tanaka R:Quality and Quantity-Cultured Human Mononuclear Cells Improve the Human Fat Graft Vascularization and Survival in an In Vivo Murine Experimental Model. Plastic and Reconstructive Surgery,147(2):373-385,2021
    

8. Tanaka R, Hirano-Ito R, Fujimura S, Arita K, Hagiwara H, Mita T, Itoh M, Kawaji H, Ogawa T, Watada H, Masuda H, Asahara T, Mizuno H: Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.Stem cell translational medicine 10 (6) :895-909. 2021
    

9. Nishikai T, Kado M, Hagiwara H, Fujimura S, Mizuno H, Tanaka R: MMP9secreted from mononuclear cell quality and quantity culture mediates STAT3phosphorylation and fibroblast migration in wounds. Regenerative Therapy 18 (2021) :464-471, 2021
    

10. Tanaka R, Fujimura S, Kado M, Fukuta T, Arita K, Hirano-Ito R, Mita T, Watada H, Kato Y, Miayuchi K, Mizuno H: Phase I/IIa Feasibility Trial of Autologous Quality- and Quantity-Cultured Peripheral Blood Mononuclear Cell Therapy for Non-Healing Extremity Ulcers. Stem Cells Translational Medicine 11(2), 146–158, 2022
     

11. Jiang S, Ito-Hirano R, Nishikai T-Yan S, Fujimura S, Mizuno H, Tanaka R: Effect of MNCQQ Cells on Migration of Human Dermal Fibroblast in Diabetic Condition. Biomedicines 10 (10): 2544, 2022
     

12. Furukawa S, Hirano R, Sugawara A, Fujimura S, Tanaka R. Serum-free quality and quantity control culture improves the angiogenic potential of peripheral blood mononuclear cells harvested from connective tissue diseases patients. Journal of Plastic and Reconstructive Surgery. 2024
     

13. Furukawa S, Hirano R, Sugawara A, Fujimura S, Tanaka R. Novel cell therapy with ex vivo cultured peripheral blood mononuclear cells significantly impacts angiogenesis in the murine ischemic limb model. Regenerative Therapy 26: 299-307, 2024